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U-shaped microRNA expression pattern could be a new concept biomarker for environmental estrogen

Rui Duan, Yun Lu, Lingyan Hou, Lina Du, Lequn Sun, Xingfan Tang

《环境科学与工程前沿(英文)》 2016年 第10卷 第6期 doi: 10.1007/s11783-016-0880-8

摘要: Estrogen regulates miRNA expression in a typical U-shaped dose-response pattern. E2 can regulate in the ventral prostate. Mouse ventral prostate is most sensitive to estrogen. Nonmonotonic dose-response in prostate could be a component of estrogen signature. Many studies have focused on environmental estrogen-related diseases. However, no consistent gene markers or signatures for estrogenicity have been discovered in mammals. This study investigated the estrogenic effects of 17β-estradiol on the prostate in immature male mice. Consistent U-shaped responses were seen in bodyweight, ventral prostate epithelial morphology, and miRNA expression levels. Specifically, most estradiol regulated miRNAs were downregulated at low doses of estradiol (0.2 and 2 mg·kg ), and whose expression returned to the control level at a larger dose (200 mg·kg ). The function of these regulated miRNAs is related to the prostate cancer and PI3K-Akt signaling pathways, which is consistent with the function of estradiol. Furthermore, the miRNA-processing machinery, Drosha, in the prostate was also regulated in a similar pattern, which could be a part of the U-shaped miRNA expression mechanism. All of these data indicate that the prostate is a reliable organ for evaluating estrogenic activity and that the typical nonmonotonic dose-response relationship could be used as a novel biomarker for estrogenicity.

关键词: miRNA     Prostate     Estradiol     Nonmonotonic dose-response     Estrogenicity     Drosha    

Low-dose CT for lung cancer screening: opportunities and challenges

null

《医学前沿(英文)》 2018年 第12卷 第1期   页码 116-121 doi: 10.1007/s11684-017-0600-1

摘要:

Lung cancer is among the most frequently diagnosed cancers worldwide and the leading cause of cancer death in both males and females. Screening for lung cancer coupled with earlier intervention has long been studied as an approach to mortality reduction. However, minimal progress was achieved until recently, when low-dose spiral computed tomography (LDCT) screening demonstrated a 20% reduction in mortality from lung cancer in a randomized controlled trial (RCT), the National Lung Screening Trial, from the United States. On the basis of this finding, LDCT has been recommended for lung cancer screening in high-risk populations by several clinical guidelines. However, results from the following independent RCTs in Europe failed to show consistent conclusions. In addition, intractable problems gradually emerged with the progress of LDCT screening. This paper summarizes and discusses the main observations and challenges of LDCT screening for lung cancer. Before spreading implementation of LDCT screening, challenges, including high false-positive rates, overdiagnosis, enormous costs, and radiation risk, must be addressed. Complementary biomarkers and technical improvement are expected in the field of lung cancer screening in the near future.

关键词: lung cancer     low-dose computerized tomography     early detection     opportunities     challenges    

Estimation of the minimum effective dose of tramadol for postoperative analgesia in infants using the

null

《医学前沿(英文)》 2012年 第6卷 第3期   页码 288-295 doi: 10.1007/s11684-012-0208-4

摘要:

Tramadol is a potent analgesic. However, the analgesia efficacy of tramadol, particularly its minimum effective dose (MED), is not clear. The aim of this study is to find MED of tramadol for postoperative analgesia in infants. The continual reassessment method (CRM) was performed to find MED. Infants undergoing surgeries were included in the 3 phases of this series. In each phase, 24 participants were allocated a different tramadol dose. Pain intensity was measured by face, legs, activity, cry, consolability (FLACC) measurement at 3-hour intervals. Tramadol was considered ineffective if the FLACC score was higher than 4 in 10 at anytime. In phase 1, seven dose levels were used within the range 0.1–0.4 mg?kg-1·h-1. Phase 1 was insufficient to identify the MED, and we increased the dose to 0.4–0.8 mg?kg-1·h-1 in phase 2. Phase 2 was insufficient to identify the MED. In phase 3, local anesthetic wound infiltration was introduced, and the tramadol dose levels tested were the same as in phase 1. The successful analgesia probability of tramadol 0.4 mg?kg-1?h-1 was 82.1% (95% CI, 0.742–0.925) in phase 1. In phase 2, it was 84.7% (95% CI, 0.789–0.991) with the dose 0.8 mg?kg-1?h-1. Phase 1 and phase 2 were insufficient to identify the MED. In phase 3, the successful analgesia probability for dose 0.35 mg?kg-1?h-1was 96.7% (95% CI, 0.853–0.997).We have demonstrated that tramadol provides insufficient analgesia for surgeries considered to cause moderate-to-severe postoperative pain in infants if used as the sole analgesic, and that local anesthetic wound infiltration enhances the efficacy of tramadol.

关键词: tramadol     minimum effective dose     postoperative analgesia     infants     continual reassessment method    

Comparison of exogenous degrader-enhanced bioremediation with low-dose persulfate oxidation for polycyclic

《环境科学与工程前沿(英文)》 2023年 第17卷 第11期 doi: 10.1007/s11783-023-1733-x

摘要: Polycyclic aromatic hydrocarbon (PAH)-contaminated soils are usually complex and characterized by a lack of nutrition and soil salinization, resulting in difficulties in soil remediation. In this study, bioaugmentation with a PAH-degrading Bacillus PheN7 (BA) and low-dose persulfate oxidation (PS), along with natural biodegradation, were utilized to remediate alkaline PAH-contaminated soil. The soil used in the study had a pH of 9.35, and the total PAH content was 568.8 ± 31.0 mg/kg dry soil. After 42 d of remediation, the degradation efficiency of PAHs was 96.72% and 93.88% using persulfate oxidation and bioaugmentation, respectively, whereas 38.66% of PAHs were degraded in natural attenuation (NA). Bacillus was the dominant genera throughout the process of bioremediation with the relative abundance of 79.3% on day 42 in the BA system, whereas, Alcanivorax was enriched and became the dominant genera in PS systems. In the meantime, PAH degradation genes were detected with remarkably higher level in the BA system than in PS system during the remediation. In addition to the degradation of contaminants, persulfate oxidation promotes microbial bioremediation efficiency mainly by lowering the pH to neutral and increasing the active phosphorus content in the soil. Microbial species and ecological niches were less reduced in the PS system than in the BA system. Collectively, persulfate oxidation had a better impact on the soil microbiome and is more suitable for long-term soil health than bioaugmentation through PheN7 addition.

关键词: Bioaugmentation     Low-dose persulfate oxidation     Polycyclic aromatic hydrocarbon     Remediation    

Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization

《医学前沿(英文)》 2022年 第16卷 第1期   页码 93-101 doi: 10.1007/s11684-021-0914-x

摘要: Inducing durable and effective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via vaccination is essential to combat the current pandemic of coronavirus disease 2019 (COVID-19). It has been noticed that the strength of anti-COVID-19 vaccination-induced immunity fades over time, which calls for an additional vaccination regime, as known as booster immunization, to restore immunity among previously vaccinated populations. Here we report a pilot open-label trial of a third dose of BBIBP-CorV, an inactivated SARS-CoV-2 vaccine (Vero cell), on 136 participants aged between 18 to 63 years. Safety and immunogenicity in terms of neutralizing antibody titers and cytokine/chemokine responses were analyzed as the main endpoint until day 28. While systemic reactogenicity was either absent or mild, SARS-CoV-2-specific neutralizing antibody titers rapidly arose in all participants within 4 weeks, surpassing the peak antibody titers elicited by the initial two-dose immunization regime. Broad increases of cellular immunity-associated cytokines and chemokines were also detected in the majority of participants after the third vaccination. Furthermore, in an exploratory study, a newly developed recombinant protein vaccine, NVSI-06-08 (CHO Cells), was found to be safe and even more effective than BBIBP-CorV in eliciting humoral immune responses in BBIBP-CorV-primed individuals. Together, these results indicate that a third immunization schedule with either homologous or heterologous vaccine showed favorable safety profiles and restored potent SARS-CoV-2-specific immunity, providing support for further trials of booster vaccination in larger populations.

关键词: COVID-19     SARS-CoV-2     vaccine     immunization     booster immunization    

An investigation on patient dose in screen-film diagnostic radiology in Lhasa City, Xizang Autonomous

null

《医学前沿(英文)》 2013年 第7卷 第4期   页码 506-509 doi: 10.1007/s11684-013-0294-y

摘要:

This study aimed to investigate patient dose in diagnostic screen-film radiographic examinations in the city of Lhasa, China. Seven out of the twenty-six hospitals registered with the Lhasa Health Bureau were included in the investigation. The entrance surface air Kerma (ESAK) of seven conventional screen-film radiology X-ray equipment in these hospitals was measured with a QA dosimeter in September 2012. The X-ray examinations were divided into three categories: PA (posterior-anterior) chest, upper/lower limb, and AP (anterior-posterior) lumbar spine. For each category, ESAKs were calculated and analyzed. The mean ESAK was 0.6 mGy for PA chest, 0.3 mGy for upper/lower limb, and 1.8 mGy for AP lumbar spine. In addition, the mean ESAK value recorded for PA chest X-ray examinations exceeded the corresponding value recommended by the International Atomic Energy Agency (0.4 mGy).

关键词: radiation dosage     radiology     radiation protection     radiography/statistics & numerical data    

Effect of chemical dose on phosphorus removal and membrane fouling control in a UCT-MBR

Guangrong Sun, Chuanyi Zhang, Wei Li, Limei Yuan, Shilong He, Liping Wang

《环境科学与工程前沿(英文)》 2019年 第13卷 第1期 doi: 10.1007/s11783-019-1085-8

摘要: To enhance phosphorus removal and make the effluent meet the strict discharge level of total phosphorus (TP, 0.5 mg/L), flocculant dosing is frequently applied. In this study, the performance of aluminum sulfate dosing in a University of Cape Town Membrane Bioreactor (UCT-MBR) was investigated, in terms of the nutrients removal performance, sludge characteristics and membrane fouling. The results indicated that the addition of aluminum sulfate into the aerobic reactor continuously had significantly enhanced phosphorus removal. Moreover, COD, NH -N and TN removal were not affected and effluent all met the first level A criteria of GB18918-2002. In addition, the addition of aluminum sulfate had improved the sludge activity slightly and reduced trans-membrane pressure (TMP) increase rate from 1.13 KPa/d to 0.57 KPa/d effectively. The membrane fouling was alleviated attributed to the increased average particle sizes and the decreased accumulation of the small sludge particles on membrane surface. Furthermore, the decline of extracellular polymeric substance (EPS) concentration in mixed sludge liquid decreased its accumulation on membrane surface, resulting in the mitigation of membrane fouling directly.

关键词: University of Cape Town Bioreactor (UCT-MBR)     enhanced nutrients removal     aluminum sulfate     sludge activity     membrane fouling    

radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes from an open-label, dose-escalation

《医学前沿(英文)》 2023年 第17卷 第2期   页码 231-239 doi: 10.1007/s11684-022-0939-9

摘要: To evaluate the safety and efficacy of neoadjuvant radiohormonal therapy for oligometastatic prostate cancer (OMPC), we conducted a 3 + 3 dose escalation, prospective, phase I/II, single-arm clinical trial (CHiCTR1900025743), in which long-term neoadjuvant androgen deprivation was adopted 1 month before radiotherapy, comprising intensity modulated radiotherapy to the pelvis, and stereotactic body radiation therapy to all extra-pelvic bone metastases for 4‒7 weeks, at 39.6, 45, 50.4, and 54 Gy. Robotic-assisted radical prostatectomy was performed after 5‒14 weeks. The primary outcome was treatment-related toxicities and adverse events; secondary outcomes were radiological treatment response, positive surgical margin (pSM), postoperative prostate-specific antigen (PSA), pathological down-grading and tumor regression grade, and survival parameters. Twelve patients were recruited from March 2019 to February 2020, aging 66.2 years in average (range, 52‒80). Median baseline PSA was 62.0 ng/mL. All underwent RARP successfully without open conversions. Ten patients recorded pathological tumor down-staging (83.3%), and 5 (41.7%) with cN1 recorded negative regional lymph nodes on final pathology. 66.7% (8/12) recorded tumor regression grading (TRG) –I and 25% (3/12) recorded TRG-II. Median follow-up was 16.5 months. Mean radiological progression-free survival (RPFS) was 21.3 months, with 2-year RPFS of 83.3%. In all, neoadjuvant radiohormonal therapy is well tolerated for oligometastatic prostate cancer.

关键词: neoadjuvant     radiotherapy     oligometastatic     prostate cancer     radical prostatectomy    

Cancer and the environment: Filling knowledge gaps together

Linda S. BIRNBAUM PhD, DABT, ATS,

《医学前沿(英文)》 2010年 第4卷 第2期   页码 131-133 doi: 10.1007/s11684-010-0044-3

摘要: When considering disease etiology, we need to view the role of the environment along the continuum from health to disease for individuals because we know that there are complex interactions between genes, their molecular expression, and environmental factors over a person’s lifetime. We clearly have huge gaps in our knowledge along this continuum, and these gaps are natural opportunities for research. There are many factors to consider as we assess the relationship between environmental exposures over a lifetime. One factor is persistence of chemicals that “live” beyond their initial intended use. Another factor is the fact that “inert ingredients” are not really inert. “Low dose” is also another consideration. We need to understand the biological effect of low dose exposure and we should clearly define what they mean by low dose research. For example, are we measuring the administered dose, or the internal/circulating dose? There are new types of toxicity as well. For example, endocrine disruptors and engineered nanomaterials are significant classes of materials deserving significant research. Timing of exposure is a significant feature in characterizing toxicity. Environmental exposures can have a greater impact in early or later life-stages. Finally, mixtures of chemicals are an important consideration. Humans are always exposed to multiple chemicals. In short, we must remember that there is no such thing as “not exposed.” Everyone has been exposed to many and various environmental agents.

关键词: environment     genes     environmental exposure     environmental agent     persistence     chemicals     inert ingredients     low dose    

Venetoclax and low-dose cytarabine induced complete remission in a patient with high-risk acute myeloid

Bingshan Liu, Roshni Narurkar, Madhura Hanmantgad, Wahib Zafar, Yongping Song, Delong Liu

《医学前沿(英文)》 2018年 第12卷 第5期   页码 593-599 doi: 10.1007/s11684-018-0635-y

摘要:

Conventional combination therapies have not resulted in considerable progress in the treatment of acute myeloid leukemia (AML). Elderly patients with AML and poor risk factors have grave prognosis. Midostaurin has been recently approved for the treatment of FLT-3-mutated AML. Venetoclax, a BCL-2 inhibitor, has been approved for the treatment of relapsed and/or refractory chronic lymphoid leukemia. Clinical trials on applying venetoclax in combination with cytarabine and other agents to treat various hematological malignancies are currently underway. Here, we present a case of a male patient with poor performance status and who developed AML following allogeneic hematopoietic stem cell transplant for high-risk myelodysplasia. The patient with high risk AML achieved complete response to the combined treatment regimen of low-dose cytarabine and venetoclax. Furthermore, we reviewed current clinical trials on the use of venetoclax for hematological malignancies.

关键词: venetoclax     cytarabine     AML     leukemia    

结合全变分最小化和稀疏字典学习后处理的低剂量CT重建 Article

Yong DING, Tuo HU

《信息与电子工程前沿(英文)》 2017年 第18卷 第12期   页码 2001-2008 doi: 10.1631/FITEE.1700287

摘要: 随着CT(computed tomography)中过量辐射剂量带来的健康风险日渐引发人们的担忧,低剂量CT得到了大量的关注。然而对于低剂量CT成像而言,在降低剂量的同时保证图像的高质量是一个很大的挑战。相比传统的滤波反投影算法,基于压缩感知的迭代重建法取得了良好的成像效果。但是迭代重建计算复杂度高,阻碍了其临床应用。本文提出一种结合全变分(total variation, TV)最小化和稀疏字典学习的重建方法,不仅提高了重建效果,而且通过自适应的停止策略提高了重建速度。实验结果表明,本文提出的方法相比其他类型的方法能获得更好的图像质量和更高的计算效率。

关键词: 低剂量CT;CT成像;全变分;稀疏字典学习    

人参皂苷CK﹑淫羊藿苷对体外培养精子的剂量负荷试验

余宏亮,常明秀,曹恒海,薄立伟,杨永俊,李聪敏,李铭

《中国工程科学》 2015年 第17卷 第6期   页码 86-88

摘要:

目的:项目拟通过观察在培养液中加入较高剂量的人参皂苷CK(Ginsenoside,G组)、淫羊藿苷(Icraiin,I组)两种药物前﹑后精子死亡率数据,评估两种药物单体在较大剂量时对体外精子的死亡率的影响。方法:新鲜液化的精液(semen)标本40份,F-10培养液调整浓度为1.0×107/mL,分别添加不同剂量的人参皂苷CK(Ginsenoside,Gin CK)﹑淫羊藿苷(Icraiin,Icr)按照不同药物浓度,G组分为500 μg/mL组(G1组),100 μg/mL组(G2组),I组分为500 μg/mL(I1组),100 μg/mL(I2组);设不添加任何物质的F-10组(F-10,F组)为阴性对照组,培养24 h后分别检查各组精子活动率和死亡率。结果:培养24 h后,精子死亡率从低到高分别是培养24 h后,I2组死亡率为41.31±17.49, F组死亡率为47.50±19.85 ,G2组死亡率为55.75±24.93,I3组死亡率为 58.05±19.06,G1组死亡率为98.84±1.62。精子死亡率从低到高分别是I2组﹑F组﹑G2组﹑I1组﹑G1组,各组比较有差异(P<0.05)。结论:较大剂量的Gin CK、Icr,均可引起体外培养的精子死亡率增高;在0.1 mg/mL的浓度下的Gin CK对精子的致死作用已经比较明显,而0.5 mg/mL对体外培养精子来说是致死剂量(98.84 %),在0.1 mg/mL的剂量下的淫羊藿苷对精子的致死作用并不明显,在0.5 mg/mL剂量下Icr对精子致死作用有所提高,但远未达到Gin CK 98.4%的致死率。

关键词: 人参皂苷CK     淫羊藿苷     精子     致死剂量    

Numerical study on laminar flame speed of natural gas-carbon monoxide-air mixtures

Chen DONG, Qulan ZHOU, Qinxin ZHAO, Tongmo XU, Shi’en HUI

《化学科学与工程前沿(英文)》 2010年 第4卷 第4期   页码 411-416 doi: 10.1007/s11705-010-0514-9

摘要: Laminar flame speeds of natural gas-carbon monoxide-air mixtures are calculated by CHEMKIN II with GRI Mech-3.0 over a large range of fuel compositions, equivalence ratios, and initial temperatures. The calculated results of natural gas are compared with previous experimental results that show a good agreement. The calculated laminar flame speeds of natural gas-carbon monoxide-air mixtures show a nonmonotonic increasing trend with volumetric fraction of carbon monoxide and an increasing trend with the increase of initial temperature of mixtures. The maximum laminar flame speed of certain fuel blend reaches its biggest value when there is 92% volumetric fraction of carbon monoxide in fuel at different initial temperatures. Five stoichiometric natural gas-carbon monoxide-air mixtures are selected to study the detailed chemical structure of natural gas-carbon monoxide-air mixtures. The results show that at stoichiometric condition, the fuel blend with 80% volumetric fraction of carbon monoxide has the biggest laminar flame speed, and the C normalized total production rate of methane with 80% volumetric fraction of carbon monoxide is the largest of the five stoichiometric mixtures.

关键词: laminar flame speed     numerical study     nonmonotonic increasing trend    

Development of a seismic design method based on response spectra for building structures

ZHOU Xiyuan, YU Ruifang

《结构与土木工程前沿(英文)》 2007年 第1卷 第2期   页码 129-141 doi: 10.1007/s11709-007-0014-2

摘要: The assumption and problem of the mode-superposition response spectrum method in seismic design code is discussed based on a brief review of the development of the seismic design method for building structures. The scope of application for the classical damping theory is analyzed and the necessity of the research on mode-superposition method for non-classical damping is presented. The progresses on the mode superposition response spectrum theory are discussed. This includes: 1) the complex mode superposition method (in real form) for the non-classically damped linear system and the general calculation formula for the application of code; 2) the complex complete quadratic combination (CCQC) method for the non-classically damped linear system, which is based on the same assumptions as in deducing the complete quadratic combination (CQC) method which is popularly used in seismic design codes of many countries; 3) the complex complete quadratic combination with three components (CCQC3) method, which is a generalization of the CCQC method to the case of multi-components and multiple-support seismic excitations and deducing corresponding method; 4) the approach for calculation of seismic response of the non-classically damped system with overcritical damping and the calculation method of seismic response for the linear system with multiple eigenvalues; 5) the time-dependent CCQC (t) algorithm considering nonstationary earthquake ground motion; 6) an applied and effective method to solve the low order complex vector basis for the large linear non-classically damped system, which can be expediently used in practice to avoid the unknown errors coming from the forced uncoupling method; 7) bringing forward the concept of partial quadratic combination in order to reduce the calculation amount of CQC and CCQC methods, and studying the primary estimation-criterion. The reasonability and applicable scope of these methods are also briefly discussed in this paper.

关键词: generalization     classical damping     mode-superposition response     calculation formula     damping theory    

Confining pressure effect on dynamic response of high rockfill dam

Xuexing CAO, Yunlong HE, Kun XIONG,

《结构与土木工程前沿(英文)》 2010年 第4卷 第1期   页码 116-126 doi: 10.1007/s11709-010-0014-5

摘要: Studies show that the dynamic properties of rockfill are strongly dependent on the confining pressure. Therefore, confining pressure effect has become a very important factor in the seismic analysis of high rockfill dam. The relationships of dynamic shear modulus versus dynamic shear strain and damping ratio versus dynamic shear strain had been improved to a certain degree on the basic of widely used Hardin-Drnevich constitutive model in this paper. Then a new model that could consider confining pressure effect has been established. Regression analysis was carried out of the dynamic triaxial experimental data of the damming materials in the Changheba hydropower station of Sichun Province, China. The results show that, the new model can fit the test data well under various confining pressures. A corresponding computational procedure was compiled and applied in the dynamic response analysis of the Changheba Dam. Comparing the calculation results between the new constitutive model and the ordinary Hardin-Drnevich model, it can be seen that the result is conservative to some extent without considering confining pressure effect.

关键词: confining pressure effect     high rockfill dam     dynamic response     Hardin-Drnevich constitutive model    

标题 作者 时间 类型 操作

U-shaped microRNA expression pattern could be a new concept biomarker for environmental estrogen

Rui Duan, Yun Lu, Lingyan Hou, Lina Du, Lequn Sun, Xingfan Tang

期刊论文

Low-dose CT for lung cancer screening: opportunities and challenges

null

期刊论文

Estimation of the minimum effective dose of tramadol for postoperative analgesia in infants using the

null

期刊论文

Comparison of exogenous degrader-enhanced bioremediation with low-dose persulfate oxidation for polycyclic

期刊论文

Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization

期刊论文

An investigation on patient dose in screen-film diagnostic radiology in Lhasa City, Xizang Autonomous

null

期刊论文

Effect of chemical dose on phosphorus removal and membrane fouling control in a UCT-MBR

Guangrong Sun, Chuanyi Zhang, Wei Li, Limei Yuan, Shilong He, Liping Wang

期刊论文

radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes from an open-label, dose-escalation

期刊论文

Cancer and the environment: Filling knowledge gaps together

Linda S. BIRNBAUM PhD, DABT, ATS,

期刊论文

Venetoclax and low-dose cytarabine induced complete remission in a patient with high-risk acute myeloid

Bingshan Liu, Roshni Narurkar, Madhura Hanmantgad, Wahib Zafar, Yongping Song, Delong Liu

期刊论文

结合全变分最小化和稀疏字典学习后处理的低剂量CT重建

Yong DING, Tuo HU

期刊论文

人参皂苷CK﹑淫羊藿苷对体外培养精子的剂量负荷试验

余宏亮,常明秀,曹恒海,薄立伟,杨永俊,李聪敏,李铭

期刊论文

Numerical study on laminar flame speed of natural gas-carbon monoxide-air mixtures

Chen DONG, Qulan ZHOU, Qinxin ZHAO, Tongmo XU, Shi’en HUI

期刊论文

Development of a seismic design method based on response spectra for building structures

ZHOU Xiyuan, YU Ruifang

期刊论文

Confining pressure effect on dynamic response of high rockfill dam

Xuexing CAO, Yunlong HE, Kun XIONG,

期刊论文